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Life Sci 80(4):275284

doi: 10.1177/0748233709104870

STORY AT-A-GLANCE Japanese professor Toru Miyazaki has discovered a potential trigger for feline chronic kidney disease (CKD) that involves the protein AIM (apoptosis inhibitor of macrophage), also known as CD5-like (CD5L) AIM is a secreted protein in the blood that supports kidney health by identifying, destroying, and removing dead cells and other debris that accumulate in the body In many cats, it seems the AIM protein cant do its job properly because it binds too tightly to IgM [immunoglobulin M] antibodies, which impedes its ability to dissociate from the antibodies and attach to the problematic debris to initiate the cleansing process Miyazaki has collaborated with both an ultraprocessed pet food producer and a pharmaceutical company in Japan to develop a food+drug companion therapy to prevent and treat CKD in cats

GHK-Cus superior performance suggests it addresses skin aging through mechanisms that complement or exceed these standard treatments

General cell culture and imaging The HeLa cell line used in this study was purchased from American Type Culture Collection (ATCC) and grown in DMEM (Gibco, 11965) media supplemented with 10% FBS and 1% 1003 Pen Strep (Gibco)
