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64 OishiK.OhkuraN.WakabayashiM.ShiraiH.SatoK.MatsudaJ.et al (2006)

These are observed phenomena in research and not definitive clinical outcomes for human application

That combination hits hydration, cellular energy and protein synthesis before anything else

In these circumstances, using methylfolate or folinic acid may be a more appropriate strategy than simply increasing folic acid intake

In contrast, if you're dealing with exotic functional groups or complex chemical effects for a small number of systems, then a quantum-chemical method is probably best
