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When differentiated into organoids, the AON-corrected line produced intestinal and kidney organoids that were indistinguishable from those derived from normal control iPSCs (data not shown), whereas the liver organoids exhibited partial recovery of ALB and CYP450 expression along with a marked attenuation of mesenchymal features (Supplementary Fig
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Mechanism by which metformin reduces glucose production in type 2 diabetes
The GSH-Px activity was measured using an indirect coupled assay and defined as proportion to the oxidation of 1nmol of nicotinamide adenine dinucleotide phosphate per minute [37]
