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This explains why overexpression of GSH2 does not affect GSH levels in unstressed plants [38,74] but under metal stress it may alleviate the depletion of GSH and enhance PC synthesis resulting in an increased metal tolerance [38]

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United States Patent Application US5906811 (A) Horiguchi H, Yurimoto H, Kato N, Sakai Y (2001) Antioxidant system within yeast peroxisome

Unfortunately, none has been established in clinical practice because of lack of large-scale and validation studies