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For example, I/R injury induces massive hepatocyte necrosis: the cell membrane of necrotic cells ruptures completely, mitochondrial structure disintegrates, and mtDNA is directly released into the extracellular fluid
6 Santini F, Vitti P, Ceccarini G, Mammoli C, Rosellini V, Pelosini C, Marsili A, Tonacchera M, Agretti P, Santoni T, Chiovato L, Pinchera A
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