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Gray MT, Woulfe JM (2015) Striatal bloodbrain barrier permeability in Parkinsons disease

In addition, ACh exerts multiple regulatory effects on the immune system: in most cases, ACh suppresses the cytotoxic function of CD8 + T cells and the inflammatory response of macrophages

It means that for a while, you wont be able to feel anything, including touch, discomfort, or cold

In healthy physiology, OPCs function as aggressive free-radical scavengers

It's a permanent loss of activity
