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This insufficient targeting leads to low NADs concentrations at the disease site and unintended gene silencing or activation, potentially causing safety issues by requiring higher doses
Zeitschrift fr Naturforschung C
The peroxidase Orp1 reduces the peroxide to give an Orp1-SOH derivative, which reacts with the Yes-associated protein 1 (Yap1) to give a mixed disulfide intermediate
But ROS can also be responsible for damage to cancerous cells
however, this has recently been put under doubt [74]
