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NIH and Office of Dietary Supplements grants HL103866, HL126827, and DK106000, and the Leducq Foundation

Se considera una tcnica mnimamente invasiva pues las microinyecciones se realizan en la zona de consulta o en sus inmediaciones (1)

Folinic acid (2 mg/kg/day, max 50 mg/day) produced significantly greater improvements in standardized verbal communication scores and several adaptive and behavioral subscales compared with placebo, with a stronger effect on children ( Furthermore, a placebo-controlled randomized trial evaluated the efficacy of folinic acid (5 mg twice daily) for 12 weeks in 19 children aged 310 years (sex distribution not reported) with ASD diagnosed by ADOS, without genetic syndromes, major medical comorbidities, or treatments affecting folate metabolism

But why exactly is this the case

J Immunol 177:26302637 Holmguist L, Stuchbury G, Berbaum K, Muscat S, Young S, Hager K, Engel J, Munch G (2007) Lipoic acid as a novel treatment for Alzheimer's disease and related dementias