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Abstract The metabolic principles underlying the differences between follicular and marginal zone B cells (FoB and MZB, respectively) are not well understood

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This bidirectionality - whereby leukemic metabolic states shape immune function, and microenvironmental signals in turn reconfigure leukemic metabolism - exemplifies the self-reinforcing circuit proposed as the organizing principle of this perspective, and identifies the convergence of oncometabolite signaling with immune checkpoint biology as a mechanistically compelling frontier for combinatorial therapeutic targeting [Figure 3]

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