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These findings and interpretations are indirectly supported by a recent report on fatigue in the long COVID-19 syndrome where lower peripheral serotonin was observed in patients than in healthy controls ( Peripheral 5-HT is produced and secreted by the enterochromaffin cells in the gastrointestinal tract where it regulates intestinal mobility

Bile acids: major regulator of the gut microbiome

The positron emission tomography (PET) was used to examine brain oxygen consumption and cerebral blood flow and revealed that patients with overt hepatic encephalopathy and those with liver cirrhosis without overt hepatic encephalopathy had a lower cerebral metabolic rate of oxygen and cerebral blood flow than healthy subjects 4

How do they work

Atherosclerosis is an inflammatory disease characterized by endothelial dysfunction