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Lough D, Dai H, Yang M et al (2013) Stimulation of the follicular bulge LGR5+ and LGR6+ stem cells with the gut-derived human alpha defensin 5 results in decreased bacterial presence, enhanced wound healing, and hair growth from tissues devoid of adnexal structures

Using too little can prevent complete dissolution, leaving some powder undissolved

These catechol estrogen metabolites can be further changed by the COMT (catechol-O-methyltransferase) enzyme or through glucuronidation ( UGT genes)

Standard protocols use 0.25-0.5 mg (250-500 mcg) daily via subcutaneous injection