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Table 2 shows a hyperbolic tapering schedule that would last well over 1 year for the Vignette patient who took venlafaxine 75 mg/day for 19 years

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Annu Rev Pharmacol Toxicol (2019) 59:55575

Novo Nordisk paused Phase 3 development due to cardiovascular safety signals identified in Phase 2 trials specifically, consistent increases in resting heart rate and blood pressure across all dose groups