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This is evident in IBDs such as Crohns whereby patients have been reported to express receptor variants to IL-23, a cytokine primarily expressed by macrophages and found in elevated abundance in the intestinal mucosa of Crohns patients (Duerr et al

10.1104/pp.110.3.807

Under normal conditions, they're kept in check by the body's clearing mechanisms

Mitochondria play crucial roles in energy conversion, ATP production, and numerous cellular signaling events [10]

Despite research efforts to understand the mechanism by which the redox signal is transmitted from oxidant to specific proteins and in particular how Grx is activated to reverse or put forward glutathionylation, much remains to be elucidated