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ATRA is a lipophilic molecule and can diffuse easily through the cellular membrane reaching the brain cells (24)

10.3389/fimmu.2018.02670 173 XuL.HuangD.HuQ.WuJ.WangY.FengJ.et al (2015)

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L-Acetyl Carnitine (ALCAR) A form of L-Carnitine that easily crosses the blood-brain barrier

Behavioral improvement after chronic administration of coenzyme Q10 in P301S transgenic mice