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Melanocortins are a large family of neuropeptides formed from a common precursor, the proopiomelanocortin molecule, which includes the adrenocorticotropic hormone (ACTH), a group (-, -, -) of melanocyte-stimulating hormones (MSH)

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These work through cofactor replenishment, metabolic signaling, or immune modulation rather than chronic GPCR hammering