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Bioinformatic predictions and humanized preclinical models will be crucial to assess the impact of these CRISPR-edited targets in humans

In addition to redox-sensitive modifications, increasing evidence suggests EAAT dysfunction in the context of Pb exposure may involve complex interactions between oxidative stress, calcium signaling, and astrocyteneuron communication

Practitioners should continue to take note of newly published reports concerning the safety of this therapeutic option in the diversity of clinical settings in which it is utilized

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