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The research so far is promising, but more studies are needed to confirm findings and refine treatment protocols

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The OINDP classification is important because it signals that standard pharmaceutical testing protocols are insufficient nasal sprays require a specialized suite of device performance tests (spray pattern, plume geometry, droplet size distribution, dose uniformity) that are specific to this dosage form and that are detailed in dedicated FDA guidance documents

58 59 Nitrous oxide toxicity The Association of British Neurologists has recently issued guidance on recognising and managing nitrous oxide toxicity associated with B 12 deficiency