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Dalton Trans (2):183194 Kasparkova J, Fojta M, Farrell N, Brabec V (2004) Differential recognition by the tumor suppressor protein p53 of DNA modified by the novel antitumor trinuclear platinum drug BBR3464 and cisplatin

Even minor fluctuations that occur repeatedly during feeding/fasting cycles, integrated over time, can cause downstream biochemical changes (e.g., 1-deoxysphingolipids) to accumulate over time and ultimately reach a threshold at which they cause disease

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4.2 Genetic models 4.2.1 SNCA models Overexpression of wild-type or mutant (A53T, A30P) -syn induces Lewy body-like inclusions in dopaminergic neurons, leading to significant neuron damage and degeneration
