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[DOI] [PubMed] [Google Scholar] 197.Bril F, Kalavalapalli S, Lomonaco R, Frye R, Godinez Leiva E, Cusi K

Subtypes of mild cognitive impairment in Parkinson's disease: progression to dementia

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They have identified four isozymes of superoxide dismutase: (i) SOD1 is a metalloprotein binding copper and zinc ions that are localized in the cytosol of the cell [55, 56], (ii) SOD2, localized in the mitochondria and it is associated with the manganese or iron ions [56, 57], (iii) SOD3, localization is extracellular and is also associated with the copper and zinc, although it has a high molecular weight [56, 58] and it has high affinity for heparin and heparin sulfates [59], and (iv) SOD4 associated with nickel and found in various aerobic bacteria found in soil of class of Streptomyces [60, 61]