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13,14 However, neutrophils are more complex than initially believed, exhibiting significant functional and phenotypic heterogeneity, particularly in pathological contexts such as inflammation and cancer, contributing to the development of various diseases

371,372 Inflammation associated with aging induces the expression of interleukin-27 receptor (IL27Ra) on the surface of HSCs through the TNF--ERK-ETS1 signaling pathway, leading to HSC senescence

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BBB Structure and function The BBB serves a critical role in maintaining CNS homeostasis by regulating the exchange of substances between the blood and the brain