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Moreover, nuclearmitochondrial genome interactions differ by sex, influencing longevity and stress adaptation, with females exhibiting more robust mitochondrial maintenanceagain, largely attributed to estrogenic signaling (Tower, 2015)

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GPER has shown promise in influencing skin pigmentation and melanoma progression, indicating that alternative mechanisms may also be crucial in modulating human pigmentation and hair graying
Because VICs are thought to be able to synthesis the right ECM, they have been utilized to construct heart valves [99]

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