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The GPCR arranges itself into a tertiary structure resembling a barrel, with the seven transmembrane helices forming a cavity within the plasma membrane that serves a ligand-binding domain that is often covered by EL-2

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doi: 10.1210/jc.2011-1995 18 RosenfeldRGCohenPRobisonLLBercuBBClaytonPHoffmanARet al

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