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For physicians practicing functional and anti-aging medicine, the critical metric is the improvement in underlying cardiovascular and metabolic markers

This trial highlights the potential of combining agents with complementary mechanisms to tackle obesity more effectively than single-drug therapies

Smoking damages blood vessels and substantially increases cardiovascular risk

Growth hormone secretagogues as potential therapeutic agents to restore growth hormone secretion in older subjects to those observed in young adults

Timing of administration relative to surgical procedures, optimal dosing in perioperative settings, and integration with standard post-operative care protocols require clinical investigation before establishing evidence-based perioperative protocols