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Inhibiting FOXO4 expression promoted apoptotic events and reduced the senescent fibroblasts viability and colony density

In a study involving 471 brain samples, RRBS was used to measure DNA methylation levels in the temporal cortex (TCX) and cerebellum (CER) ( 3.3 Methylation arrays (e.g., Infinium 450K/850K) Methylation arrays are high-throughput tools for analyzing DNA methylation across the genome, including CpG islands, promoters, and enhancers (57, 58)

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Embryos with optimal cleavage timing show coordinated expression of cell cycle genes and metabolic regulators, while delayed development correlates with altered gene expression patterns and metabolic dysfunction [433, 434]