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Whilst the exact pathophysiology of PD still remains unclear, it is believed microvascular trauma, initiated by penile damage during sexual activity or due to repetitive minor trauma, leading to increased proliferation of fibroblasts and recruitment of profibrotic mediators leads to an excessive deposition of collagen

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Carnitine is involved in transporting long-chain fatty acids into the mitochondria, where they are metabolised to produce energy

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Inhibition of ACL by bempedoic acid decreases hepatic cholesterol synthesis and reduces blood LDL-C concentration by increasing the activity of LDL receptors

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