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Matching with these findings, bulk transcriptomic profiling of cerebellar tissues harvested from 6-month-old mice revealed that differentially downregulated genes were highly involved in glycolysis, adipogenesis (i.e., lipid anabolism), and myogenesis (i.e., protein anabolism) (Supplementary Fig

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[42] Glucose-6-phosphate dehydrogenase 6-phosphogluconic dehydrogenase