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Mechanistically, TDP43 expression attenuated mitochondrial membrane potential, suppressed mitochondrial complex I activity, and impaired mitochondrial ATP synthesis

A separate cohort study from the Philippines demonstrated even more striking results: patients receiving 30 mL per day for 14 days achieved favorable outcomes in 87% of cases, compared to just 50% in the control group

Second, although ARPE-19 cells are a common model for studying retinal function [68, 69], their standard culture medium already contains elevated glucose levels higher than physiological norms

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Additionally, while FOXO4-DRI has been shown to limit chemotoxicity in certain contexts, its overall safety profile in humans requires further research to fully understand all potential side effects