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The following will provide an overview of their mechanisms of action

Nasal delivery bypasses first-pass metabolism and allows direct transport to the systemic circulation and liver via the olfactory nerve, while rectal administration avoids gastric acid degradation and enhances local absorption in the colon

Chronic glial activation exacerbates ferroptosis

Cell Biosci 10:117

Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes
