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10.1111/j.1469-7610.2004.00221.x 68 MehtaM

10.1016/j.addr.2013.09.001 Adv

Right panel : High-dose IV ACh causes more profound systemic vasodilation and additionally exerts direct effects on cardiac M2 receptors in the sinoatrial (SA) node, suppressing pacemaker activity
Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology

While the theoretical rationale is sound, no clinical trial has tested this specific combination, and the safety profile of triple-pathway activation through separate compounds is unknown
