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Most users continue treatment without intervention, and symptoms resolve spontaneously

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Price D, Scadding G, Ryan D, Bachert C, Canonica GW, Mullol J, et al

80 Clinical trials using lower doses of folic acid (400 mcg5 mg [6808,500 mcg DFE]) along with other supplements such as zinc, vitamin E, and selenium have not been able to consistently demonstrate benefits on semen parameters or pregnancy rates

A 2020 study demonstrated that the AEDG peptide increased expression of neurogenic differentiation markers (Nestin, GAP43, -Tubulin III, Doublecortin) by 1.61.8-fold in human mesenchymal stem cells (9)