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The core principle here is creating a solution with a known concentration
Temporal and Spatial Expression of HGF-MET in the Postnatal Developing Brain Sites of HGF and MET expression in the postnatal brain include the CA-1 area of hippocampus and limited regions of the cortex (Jung et al., 1994
Thus, tPA increases BBB permeability, and the risk of hemorrhagic transformation

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