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You may need to adjust your daily intake based on your individual needs and/or health history

Retrieved May 3, 2025, from [ \- Link Opens in New Tab]( (Cautions that people with low blood pressure or a history of gout should not take niacin/niacinamide due to risk of hypotension and hyperuricemia

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Alcohol and certain medications like colchicine can also interact with B12, so we'll review all your medications and supplements before starting treatment

Absorption of vitamin B 12 is inhibited from both dietary sources and from the bile (enterohepatic circulation) and thus depletion of vitamin B 12 body stores can occur relatively quickly