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Neurology 1991;41:1726-32

Furthermore, TMAO has been found to enhance macrophage infiltration, promote M1 polarization, and stimulate Th1 and Th17 differentiation in allogeneic graft-versus-host disease (77)
doi: 10.1111/1750-3841.13711 30

Further evidence that the production of TMAO is dependent on metabolism by intestinal microbiota is provided by studies in healthy humans given phosphatidylcholine challenge, in which the plasma levels of TMAO were suppressed by oral administration of broad spectrum antibiotics [14]