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In models of aging and AD, long-term administration of melatonin appears to inhibit neurodegeneration, improve cognitive function, reduce amyloid deposits and tau phosphorylation, and reduce microglial activation and inflammatory cytokines [127,128,129,130]

LDL receptor-related protein-1: a regulator of inflammation in atherosclerosis, cancer, and injury to the nervous system

In cerebral I/R injury, increases in thrombin in neurons activate cPLA2 and promote the release of arachidonic acid, which is esterified by ACSL4 and utilized as a ferroptotic fuel

component amino acids are reabsorbed and reconstituted intracellularly

This multifunctional agent offers a promising approach for future PTT drug development