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Tirzepatide reconstitution by vial size (units assume U-100 insulin syringes) Vial 5 mg BAC water 1.0 mL Concentration 5 mg/mL 2.5 mg 0.50 mL / 50 u 5 mg 1.00 mL / 100 u 7.5 mg 10 mg 15 mg Vial 10 mg BAC water 1.0 mL Concentration 10 mg/mL 2.5 mg 0.25 mL / 25 u 5 mg 0.50 mL / 50 u 7.5 mg 0.75 mL / 75 u 10 mg 1.00 mL / 100 u 15 mg Vial 10 mg BAC water 2.0 mL Concentration 5 mg/mL 2.5 mg 0.50 mL / 50 u 5 mg 1.00 mL / 100 u 7.5 mg 10 mg 15 mg Vial 15 mg BAC water 1.5 mL Concentration 10 mg/mL 2.5 mg 0.25 mL / 25 u 5 mg 0.50 mL / 50 u 7.5 mg 0.75 mL / 75 u 10 mg 1.00 mL / 100 u 15 mg 1.50 mL / split Vial 40 mg BAC water 2.0 mL Concentration 20 mg/mL 2.5 mg 0.125 mL / 12.5 u 5 mg 0.25 mL / 25 u 7.5 mg 0.375 mL / 37.5 u 10 mg 0.50 mL / 50 u 15 mg 0.75 mL / 75 u Vial 40 mg BAC water 3.0 mL Concentration 13.33 mg/mL 2.5 mg 0.188 mL / 18.8 u 5 mg 0.375 mL / 37.5 u 7.5 mg 0.563 mL / 56.3 u 10 mg 0.75 mL / 75 u 15 mg 1.125 mL / split Vial 60 mg BAC water 3.0 mL Concentration 20 mg/mL 2.5 mg 0.125 mL / 12.5 u 5 mg 0.25 mL / 25 u 7.5 mg 0.375 mL / 37.5 u 10 mg 0.50 mL / 50 u 15 mg 0.75 mL / 75 u 20 mg/mL keeps 40 mg and 60 mg vial setups within a 3 mL vial-capacity ceiling while keeping the listed doses compact

On the other hand, as a new attempt, from the cytoprotection viewpoint and potential involvement of the cytoprotective agents, we reviewed the potential significance in the heart disturbances of the therapy with the stable gastric pentadecapeptide BPC 157 (for review, see, i.e., [2,3,4,5,6,7,8,9])

Children and pregnant women are not eligible

Women of childbearing age should use contraception while on tirzepatide and discontinue the medication at least 2 months before attempting conception to allow complete washout given the long half-life