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Astragaloside IV can also enhance pancreatic beta cell dysfunction induced by uric acid through the activation of the PI3K/AKT pathway, anti-apoptotic effects, and activation of autophagy (Zhang et al., 2021)

Considering that spermatozoa are exposed to both internally produced ROS and those present in the seminal plasma due to external factors such as smoking, alcohol, heat, and others, determining their levels is of fundamental importance as they can be a cause of reduced sperm quality with a decrease in motility and vitality and increased sperm DNA fragmentation [38,39,40]

J Clin Med 2022;11:1781

36 Increased risk of cardiovascular-kidney-metabolic disease Cardiovascular-kidney-MetS is a systemic disease caused by the pathophysiological interactions between cardiometabolic risk factors, CKD, and CVD, with NAFLD playing a central role as a metabolic condition

Figure 5 Our in vitro studies predicted that erythrocyte toxicity would limit the antimalarial efficacy of the prodrug POM-HEX, which penetrates cells easily, leading to comparable erythrotoxic and antimalarial potencies ( Table 1 )