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They interfere with the proliferation of cancer cells by downregulating the signal transduction pathways including mammalian target of rapamycin (mTOR), nuclear factor kappa-light-chain enhancer of activated B cells (NF-kB) and signal transducer and activator of transcription-3 (STAT3) etc

The introduction into cells of the MDR2 gene did not result in drug resistance [15]

Salete-Granado et al., 2023)

Influence of mutation type on clinical expression of Leber hereditary optic neuropathy

Retatrutides balanced triple-receptor activity may offer a pathway for these outliers, providing an alternative mechanism for metabolic signaling that bypasses specific points of resistance in the dual-agonist pathway