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As Mancini (2018) points out, The neuroprotective effect of coffee consumption is likely due to a combination of factors. The cocktail of compounds works concurrently to impact positively a range of human health conditions

Cancer 104, 15641574

PubMed Effects of Semax on the Default Mode Network of the Brain Small human fMRI study (24 adults) of intranasal Semax on brain networks

In parallel, CLOCK-BMAL1 recruits CUL4A-DDB1 to circadian target genes such as PER1, PER2, and CRY1, where it catalyzes rhythmic histone H2B monoubiquitination at E-box sites (Tamayo et al., 2015)
Cluster marker gene detection was performed using Wilcoxon Rank Sum tests with multiple testing corrections (Bonferroni)
