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In a 2017 endotoxemia model, TB-500 at 100 mcg/kg intraperitoneal injection reduced serum TNF-, IL-1, and IL-6 by 40 to 55% within four hours of LPS challenge

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These findings not only enrich the molecular understanding of senescent cell clearance but also provide a novel strategy for precise targeting of endothelial cell senescence in therapeutic applications

doi: 10.1016/j.neuro.2010.05.008 36 MolesLEgimendiaAOsorio-QuerejetaIIparraguirreLAlberroASurezJet al
