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Mouse Studies All mice were intraperitonially injected with 100L tamoxifen (Cayman Chemical, 13258) on alternating abdominal sides for 5 consecutive days

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In DNCB-induced AD mouse models, systemic administration of the Vitamin D metabolite calcifediol markedly improved barrier function, evidenced by reduced transepidermal water loss, alleviation of stratum spinosum hyperplasia, and downregulation of the water-channel protein AQP3 [231]