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In the TME, despite various ammonia clearance mechanisms, rapidly proliferating cells, particularly tumor and immune effector cells, have a heightened demand for -KG derived from glutamine breakdown to fuel the TCA cycle, leading to substantial free ammonia production (103)

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Senescent cells and macrophages: key players for regeneration

Injectable BPC-157 is generally considered the most effective due to its higher bioavailability and direct delivery to the bloodstream

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