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However, the predominance of in vitro and acute in vivo models highlights the need for systematic evaluation of long-term safety, biodistribution, and translational relevance in clinically relevant neurological settings [151153]
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Patients might notice a decline in mental clarity, difficulty concentrating, or uncharacteristic mood changes

95% CI, 1.02-2.04), but this study did not find an association between plasma concentrations of vitamin B 12 and breast cancer (55)

Many patients begin noticing changes in energy and appetite regulation within weeks
