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16 Although NAM ranks as the most efficient substrate for NNMT, other heterocyclic compounds including thionicotinamide, 4-methylnicotinamide, isoquinoline, quinoline, and tetrahydroquinoline can also be effectively methylated by NNMT

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Therefore, if we do not rescale HCI, we will be deemphasizing the importance of HCI for the SFP as a relevant dimension of care quality because the range of possible values for HCI is much smaller than the range of possible values for quality-of-care CLDs and substantiated complaints

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