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Description
Many nonsteroidal anti-inflammatory drugs such as aspirin or ibuprofen act by blocking COX-2, which is stimulated by many cytokines and growth factors [86]
Severe hypokalaemia (low blood potassium) is rare but can develop in some cases, particularly in severe megaloblastic anaemia or in patients taking certain medications such as diuretics

The regulatory effects of exercise and metformin on biomarkers in obesity: a focus on uric acid, irisin, adiponutrin, adropin, and copeptin

10.1016/j.jmb.2006.06.026

Until this day, the exact cause of the disorder remains unknown
