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Embodiment 169 A method of reducing tumor initiating cells in a cell population, the method comprising contacting a cell population, wherein the population comprises tumor initiating cells that express ALPPL2 and cells other than tumor initiating cells, with an anti-ALPPL2 immunoconjugate according to any one of embodiments 136- 164, wherein the effector comprising said immunoconjugate has cytostatic and/or cytotoxic activity and/or immunomodulatory activity, whereby the frequency of tumor initiating cells in the tumor cell population is reduced

Biomedicines 10:891

17 , 11451153 (2018a)

Interestingly, oral BPC-157 may still provide local benefits for gastrointestinal conditions by exerting effects directly on the gut lining before being degraded

Monitoring recommendations: Check blood pressure before first use to establish baseline