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J Tehran Univ Heart Center 10(2):74 DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, OKeefe JH, Elsevier Ltd (2013) L-Carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis

Theoretically, higher PDC flux during strenuous exercise would be expected to reduce blood lactate (BL) accumulation, which could potentially preserve glycogen stores and subsequently delay premature fatigue 3,4

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Another Phase III, double-blind, placebo-controlled trial with 234 severe CFS patients showed that rintatolimod yielded a 21.3% placebo-adjusted improvement in exercise tolerance by Week 40