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An alternative hypothesis is that there is some structural property of the gene that renders it particularly susceptible to mutation

The uptake of [ 3 H]GABA by slices of rat cerebral cortex

[88] A 2014 study found that the low level of methylation in fruit flies appeared "at specific short motifs and is independent of DNMT2 activity." [89] Further, highly sensitive mass spectrometry approaches, [90] have now demonstrated the presence of low (0.07%) but significant levels of adenine methylation during the earliest stages of Drosophila embryogenesis

Masalha et al

Most patients (76%) had experienced disease progression while receiving sorafenib or lenvatinib