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Mechanism of Action Melanotan 1 has been investigated for its potent and selective agonism of the melanocortin 1 receptor (MC1R), a Gs-coupled GPCR expressed on melanocytes and other cell types

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After treatment with carglumic acid, there were no clinical symptoms in 8 of 30 (27%) episodes with available baseline and endpoint data

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The risk of CAD among individuals with definite or probable HeFH is estimated to be increased at least 10-fold18

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Not appropriate during pregnancy or breastfeeding Melanotan II is not used during pregnancy or breastfeeding

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