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Dig Dis Sci [Internet]

In parallel, it inhibits activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) pathway and suppresses NLRP3 inflammasome activation, resulting in decreased production of inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF)

Hot-plate pain testing involves central COX mechanisms, whereas abdominal writhing measures peripheral COX enzyme effects, indicating that B12 may have both central and peripheral COX inhibiting properties (29)

The level of 3-bromotyrosine, a unique product of EPO and eosinophils, was found to be 3 times higher in the bronchoalveolar lavage (BAL) fluid of individuals with asthma compared with that in the control subjects [31]

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