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Effects on dopamine and serotonin systems address neurotransmitter dysregulation

Whereas protective effects of lipophilic RTAs in renal IRI have been corroborated by genetic approaches, this type of evidence falls short for most other models of acute kidney injury

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The nAChRs can respond to a relatively low concentration that can be safely attained in the extra-synaptic region, which lends support to the concept of a comparable paracrine wide distance range known as volume transmission [16]
